NEW YORK (CNN/Money) - A new study shows that erectile dysfunction drugs such as Cialis and Levitra might also be responsible for the death toll of Viagra's blockbuster patent-protected patent for impotence treatment Viagra. In a new study published in the New England Journal of Medicine, the research was led by a team of researchers led by Dr. Robert H. Johnson of Duke University, who is now co-director of the Duke Medical Center and the Duke Veterans Affairs Medical Center.
"Erectile dysfunction drugs have been shown to be associated with a range of potentially dangerous side effects, including erectile dysfunction," said study author Dr. Daniel A. Pappas of Duke University.
The study was led by a group of researchers at the Medical College of Georgia who was not involved in the study, who had a similar interest in the work. Johnson is the principal investigator in the study.
The researchers tested the drugs' effectiveness on male impotent patients.
"When male patients were treated with Cialis or Levitra, the incidence of sexual dysfunction was significantly higher in patients who were treated with these drugs," said Pappas. "The incidence of erectile dysfunction was also significantly higher in the Cialis patients who also took nitrates."
The study, published in the JAMA Internal Medicine, showed that Cialis and Levitra were significantly more effective than Viagra in treating men with erectile dysfunction.
"While this finding is in line with our earlier work, our study provides further evidence that erectile dysfunction drugs may have potentially harmful side effects, particularly for impotent men," Pappas said. "We hope that this research will be of value in improving our understanding of erectile dysfunction in patients."
The study was based on two separate clinical trials. The first trial, published in 2003, focused on patients who had a history of erectile dysfunction.
The second trial, published in 2006, examined the effect of Viagra on the risk of developing erectile dysfunction.
"A key finding was that Viagra may have a greater effect on patients with erectile dysfunction than on healthy controls," Pappas said. "In fact, Viagra was shown to be the best treatment for patients with erectile dysfunction when compared with patients who did not have erectile dysfunction."
The new study will provide further evidence of the effectiveness of Cialis and Levitra in treating erectile dysfunction, Pappas said. "The fact that the trials involved men with erectile dysfunction who were treated with both Cialis and Levitra suggests that Cialis and Levitra could be effective treatments for ED in men with erectile dysfunction," Pappas said.
Cialis is approved by the Food and Drug Administration for the treatment of erectile dysfunction, a condition that involves the inability to attain or maintain an erection sufficient for sexual activity. It is also prescribed as an erectile dysfunction treatment for adult men with impotence or other sexual problems. Cialis also may also be used off-label for the treatment of benign prostatic hyperplasia (BPH) or for the treatment of erectile dysfunction in women.
Levitra is approved by the FDA for the treatment of erectile dysfunction and also for the treatment of male impotence in patients with other medical conditions. Levitra may also be used off-label for the treatment of benign prostatic hyperplasia or for the treatment of erectile dysfunction in women. Both Cialis and Levitra are FDA-approved for the treatment of both male and female impotence.
The new study is published in the journal American Journal of Clinical Orthopaedic Research.
Credit: Getty Images/ThinkstockRead MoreThe study was sponsored by Duke Medical Center's Division of Orthopedic Surgery and Duke University's Department of Pediatrics and the Department of Surgery at the Duke Veterans Affairs Medical Center.
Dr. Robert Johnson, who was not involved in the research, is the research associate principal investigator in the study. He is currently professor of orthopaedic surgery at Duke.
Johnson is a professor of orthopaedic surgery at Duke and director of the Duke University's Division of Orthopedic Surgery.
During the study, the researchers measured the erectile function of male subjects, taking blood tests, and measured the effects of Cialis or Levitra on the erectile function of healthy male volunteers. The effects of Cialis or Levitra were also evaluated in healthy male volunteers.
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Viagra (sildenafil) is used to treat erectile dysfunction. Erectile dysfunction is the inability to get or keep an erection for satisfactory sexual activity in men, also known as impotence. Sildenafil belongs to a class of medications called phosphodiesterase type5 (PDE5) inhibitors. Viagra works by relaxing muscles found in the walls of blood vessels and increasing blood flow to the penis during sexual stimulation to get and keep an erection. Keep in mind that Viagra does not cure erectile dysfunction or increase sexual desire.
under the brand Revatio is also used to treat pulmonary atrial hypertension (PAH). If you are taking Revatio do not take Viagra unless directed by your physician.
The recommended dose is 50mg about 1 hour before sexual activity, but it can be taken from 30 minutes to 4 hours before intercourse. The maximum daily dosage is once per day, with or without food. The dosage can be increased to 100mg or decreased to 25mg based on toleration and effectiveness. Viagra 100mg are available in KamaHealth.
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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
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